Cunningham Miles G, Ames Heather M, Christensen Mette-Kirstine, Sorensen Jens Christian
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Neuroreport. 2007 Apr 16;18(6):531-5. doi: 10.1097/WNR.0b013e328091c212.
The basolateral amygdaloid complex is a site of origin for zinc-containing pathways in the brain; it is also known for its massive innervation of the medial prefrontal cortex. The presence, and potential neuromodulatory role, of zinc within this fundamental corticolimbic circuit has not been described. For this study, basolateral neurons innervating the medial prefrontal cortex were retrogradely labeled with FluoroGold, and zinc-containing neurons were identified using autometallography to visualize zinc selenium precipitates. Upon quantification of single-labeled and double-labeled cells, 35% of basolateral neurons projecting to medial prefrontal cortex were found to also contain zinc. We conclude that zinc may act as a neuromodulator for a substantial proportion of basolateral-medial prefrontal cortical innervation, therefore implicating zinc in corticolimbic function as well as pathology.
基底外侧杏仁核复合体是大脑中含锌通路的起源部位；它还因其对内侧前额叶皮质的大量神经支配而闻名。在这个基本的皮质边缘回路中，锌的存在及其潜在的神经调节作用尚未被描述。在本研究中，用荧光金逆行标记支配内侧前额叶皮质的基底外侧神经元，并使用自动金相术识别含锌神经元，以可视化锌硒沉淀物。对单标记和双标记细胞进行定量分析后发现，投射到内侧前额叶皮质的基底外侧神经元中有35%也含有锌。我们得出结论，锌可能作为一种神经调节剂，作用于相当一部分基底外侧-内侧前额叶皮质神经支配，因此表明锌与皮质边缘功能以及病理学有关。
