6-甲硫基肌苷3',5'-环一磷酸对核苷耐药肿瘤细胞的反馈抑制作用
Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside.
作者信息
Epps D, Chang I M, Sherwood E, Kimball A P
出版信息
Proc Soc Exp Biol Med. 1975 Dec;150(3):578-80. doi: 10.3181/00379727-150-39083.
PMID:174138
Abstract
The 3',5'-cyclic phosphate derivative (cMTIMP) of methylthioinosine (MTI) was shown to produce feedback inhibition of the de novo purine pathway in an Ehrlich ascites tumor subline resistant to MTI because of lack of adenosine kinase activity for the nucleoside analog.
摘要
由于对核苷类似物甲硫基肌苷（MTI）缺乏腺苷激酶活性，甲硫基肌苷（MTI）的3'，5'-环磷酸衍生物（cMTIMP）在对MTI耐药的艾氏腹水瘤亚系中对嘌呤从头合成途径产生反馈抑制作用。
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