Hitzenberger G
Arzneimittelforschung. 1977;27(3a):700-2.
The pathophysiology of the coronary insufficiency, the effect of beta-receptor antagonists, the understanding of these effects on the basis of the pathophysiology and the possibilities of testing beta-receptor antagonists in patients with coronary insufficiency are discussed. It is pointed out that the pathophysiology of the coronary insufficiency is based on the difference between oxygen demand of and oxygen supply to the myocardium. beta-Receptor antagonists compensate for this difference. Testing beta-receptor antagonists should include tolerance to exercise and controlled studies using standard medication for comparison.
讨论了冠状动脉供血不足的病理生理学、β受体拮抗剂的作用、基于病理生理学对这些作用的理解以及在冠状动脉供血不足患者中测试β受体拮抗剂的可能性。指出冠状动脉供血不足的病理生理学基于心肌需氧量和供氧量之间的差异。β受体拮抗剂可弥补这种差异。测试β受体拮抗剂应包括运动耐受性以及使用标准药物进行对照研究以作比较。