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在加纳将B型流感嗜血杆菌结合疫苗纳入常规免疫及其对五岁以下儿童细菌性脑膜炎的影响。

Introduction of Haemophilus influenzae type B conjugate vaccine into routine immunization in Ghana and its impact on bacterial meningitis in children younger than five years.

作者信息

Renner Lorna Awo, Newman Mercy J, Ahadzie Lawson, Antwi-Agyei Kwadwo Odei, Eshetu Messeret

机构信息

Department of Child Health, University of Ghana Medical School, Accra, Ghana.

出版信息

Pediatr Infect Dis J. 2007 Apr;26(4):356-8. doi: 10.1097/01.inf.0000258693.19247.8e.

DOI:10.1097/01.inf.0000258693.19247.8e
PMID:17414404
Abstract

This report shows the impact of a pentavalent vaccine that includes Haemophilus influenzae type b (Hib) conjugate vaccine on bacterial meningitis in children younger than 5 years in Ghana. A review of the first 3 years of a pediatric bacterial meningitis surveillance program, started in August 2001 in Accra, Ghana, was undertaken. There was a significant reduction, P = 0.042 and 0.017, in percentage of purulent meningitis in children younger than 1 year, comparing the first year when the vaccine was introduced, to the second and third years, respectively.

摘要

本报告展示了一种包含b型流感嗜血杆菌(Hib)结合疫苗的五价疫苗对加纳5岁以下儿童细菌性脑膜炎的影响。对2001年8月在加纳阿克拉启动的儿科细菌性脑膜炎监测项目的头3年进行了回顾。将引入疫苗的第一年分别与第二年和第三年相比,1岁以下儿童化脓性脑膜炎的百分比有显著降低,P值分别为0.042和0.017。

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