Solntseva E I, Bukanova Yu V, Skrebitskii V G
Institute of Brain Research, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2006 Oct;142(4):387-90. doi: 10.1007/s10517-006-0372-0.
The effects of donepezil on voltage-dependent Ca(2+)- and low-threshold K(+)-current were studied on isolated molluscan neurons using two-electrode voltage clamp technique. Donepezil reduced the amplitude of voltage-dependent Ca(2+)-current (IC(50)=7.9 microM) and shifted the current-voltage relationships toward hyperpolarization. Donepezil in low concentration (5 microM) increased, while in higher concentrations (>or=10 microM) decreased the low-threshold K(+)-current.
