Kaloshi Gentian, Mokhtari Karima, Carpentier Catherine, Taillibert Sophie, Lejeune Julie, Marie Yannick, Delattre Jean-Yves, Godbout Roseline, Sanson Marc
Service de Neurologie Mazarin, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, and INSERM, U711, Biologie des Interactions Neurones & Glie, Faculté de Médecine, Université Pierre et Marie Curie, Paris, Cedex 13, 75651, France.
J Neurooncol. 2007 Sep;84(3):245-8. doi: 10.1007/s11060-007-9377-4. Epub 2007 Apr 6.
FABP7 expression has been analysed in a series of 123 glioblastomas (68 pure GBM, 55 GBMO, i.e. with oligodendroglial component). FABP7, found in 91/123 samples, showed a pure cytoplasmic expression in 69 cases, and cytoplasmic+nuclear expression in 22 cases. FABP7 expression was associated with pure GBM histology and shorter survival (15.7 months versus 21.5 months). Nuclear expression of FABP7 was more specifically related to EGFR amplification and more invasive tumors. These data, although they need to be confirmed by further studies, support the relation between FABP7, astrocytic features, invasion and poor prognosis and suggests that EGFR amplification is associated with nuclear translocation of FABP7.
在123例胶质母细胞瘤（68例单纯胶质母细胞瘤，55例胶质母细胞瘤伴少突胶质细胞成分，即GBMO）中分析了脂肪酸结合蛋白7（FABP7）的表达情况。在123个样本中的91个样本中检测到FABP7，其中69例显示为单纯细胞质表达，22例显示为细胞质+细胞核表达。FABP7表达与单纯胶质母细胞瘤组织学类型相关，且生存期较短（15.7个月对21.5个月）。FABP7的细胞核表达更具体地与表皮生长因子受体（EGFR）扩增和侵袭性更强的肿瘤相关。这些数据虽然需要进一步研究来证实，但支持了FABP7、星形细胞特征、侵袭和预后不良之间的关系，并表明EGFR扩增与FABP7的核转位有关。
