Neurosurgical Department, Clinical Hospital "Bagdasar-Arseni", 041915 Bucharest, Romania.
Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania.
Int J Mol Sci. 2022 Apr 21;23(9):4602. doi: 10.3390/ijms23094602.
Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most standard treatments fail to completely eradicate GSCs, causing the recurrence of the disease. GSCs could represent one reason for the low efficacy of cancer therapy and for the short relapse time. Nonetheless, experimental data suggest that the presence of therapy-resistant GSCs could explain tumor recurrence. Therefore, to effectively target GSCs, a comprehensive understanding of their biology and the survival and developing mechanisms during treatment is mandatory. This review provides an overview of the molecular features, microenvironment, detection, and targeting strategies of GSCs, an essential information required for an efficient therapy. Despite the outstanding results in oncology, researchers are still developing novel strategies, of which one could be targeting the GSCs present in the hypoxic regions and invasive edge of the glioblastoma.
胶质母细胞瘤干细胞（GSCs）是一类具有自我更新能力和能够在连续移植后引发肿瘤的细胞，它们与肿瘤细胞异质性有关。大多数标准治疗方法都无法完全清除 GSCs，导致疾病复发。GSCs 可能是癌症治疗效果低和复发时间短的一个原因。尽管如此，实验数据表明，存在对治疗有抗性的 GSCs 可能解释了肿瘤的复发。因此，为了有效地靶向 GSCs，必须全面了解它们的生物学特性，以及在治疗过程中的生存和发展机制。这篇综述提供了 GSCs 的分子特征、微环境、检测和靶向策略的概述，这是有效治疗所必需的重要信息。尽管在肿瘤学方面取得了显著的成果，研究人员仍在开发新的策略，其中一种策略可能是针对胶质母细胞瘤中缺氧区域和侵袭边缘存在的 GSCs。
