Peña Griñán M J, Lluch Fernández M D, Montoya García M J, Ramos Sánchez I, Pérez Cano R
Departamento de Pediatría, Hospital Universitario Virgen Macarena, Sevilla.
An Esp Pediatr. 1991 Sep;35(3):169-72.
Comparative assessments were made regarding the effects of prolonged administration of anticonvulsant drugs (phenobarbital, carbamazepine, valproate and polytherapy) on the different biochemical parameters related to phosphocalcium metabolism, in 98 children between 1 and 14 years. The most patent effect was on the levels of 25-Hydroxycholecalciferol which went down significantly (p = 0.0001) in children treated with phenobarbital (34.5 +/- 17 ng/ml) or polytherapy (28.4 +/- 18 ng/ml) in relation to those treated with carbamazepine (49.2 +/- 15 ng/ml) or valproate (43.1 +/- 15 ng/ml) and to control group (45.9 +/- 13 ng/ml). The alkaline phosphatase has been found significantly higher among those treated with phenobarbital, carbamazepine and polytherapy, evidencing significant differences in relation to those treated with valproate and to control group (p less than 0.05). For calcium, parathyroid hormone and osteocalcine levels no differences were found in the different drugs, nor with control group. Depending on the duration of treatment there was a significant reduction (p = 0.02) in the levels of 25-Hydroxycholecalciferol in children treated over 3 years, but no difference for calcium, phosphorous, alkaline phosphatase and PTH under this parameter.
对98名1至14岁儿童进行了比较评估，以研究长期服用抗惊厥药物（苯巴比妥、卡马西平、丙戊酸盐及联合治疗）对与磷钙代谢相关的不同生化参数的影响。最明显的影响体现在25-羟胆钙化醇水平上，服用苯巴比妥（34.5±17 ng/ml）或联合治疗（28.4±18 ng/ml）的儿童，其25-羟胆钙化醇水平相较于服用卡马西平（49.2±15 ng/ml）或丙戊酸盐（43.1±15 ng/ml）的儿童以及对照组（45.9±13 ng/ml）显著下降（p = 0.0001）。在服用苯巴比妥、卡马西平和联合治疗的儿童中，碱性磷酸酶水平显著更高，与服用丙戊酸盐的儿童及对照组相比存在显著差异（p＜0.05）。对于钙、甲状旁腺激素和骨钙素水平，不同药物组之间以及与对照组相比均未发现差异。根据治疗持续时间，治疗超过3年的儿童25-羟胆钙化醇水平显著降低（p = 0.02），但在此参数下，钙、磷、碱性磷酸酶和甲状旁腺激素水平无差异。
