[纵隔原发性生殖细胞肿瘤——47例报告]

[Primary germ cell tumor in the mediastinum-report of 47 cases].

作者信息

Zhou Zheng-tao, Wang Jin-wan, Yang Lin, Wang Jing, Zhang Wen

机构信息

Department of Medical Oncology, Cancer Hospital (Institute), Chinese Academy Of Medical Sciences, Peking Union Medical College, Beijing 100021, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2006 Nov;28(11):863-6.

PMID:17416013

Abstract

OBJECTIVE

To investigate the clinical characterstics, effective treatment and prognosis in patients with primary germ cell tumors in the mediastinum.

METHODS

The data of 47 such patients treated from 1967 to 2005 were retrospectively reviewed.

RESULTS

Of these 47 patients, 41 were male and 6 female with a median age of 26 years; 8 (17.0%) had seminoma, and 39 (83.0%) non-seminoma. The overall 1-, 3-, 5-year survival rate was 63.4%, 37.5% and 34.8% with a median survival time of 16 months; which was 100%, 83.3% and 83.3% for seminoma and 56.4%, 30% and 27.3% for nonseminoma, respectively. The pathologic type was found to be the only independent prognostic factor (P = 0.045).

CONCLUSION

Primary mediastinal serminoma is sensitive to radiotherapy or chemotherapy with a good prognosis, but the prognosis of primary mediastinal non-seminoma is poor. Cisplatin-based chemotherapy still plays a key role in the treatment of primary mediastinal non-seminoma as the survival of those has been improved.

摘要

目的

探讨纵隔原发性生殖细胞肿瘤患者的临床特征、有效治疗方法及预后。

方法

回顾性分析1967年至2005年期间治疗的47例此类患者的数据。

结果

这47例患者中，男性41例，女性6例，中位年龄26岁；精原细胞瘤8例（17.0%），非精原细胞瘤39例（83.0%）。总体1年、3年、5年生存率分别为63.4%、37.5%和34.8%，中位生存时间为16个月；精原细胞瘤分别为100%、83.3%和83.3%，非精原细胞瘤分别为56.4%、30%和27.3%。病理类型是唯一的独立预后因素（P = 0.045）。