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[糖尿病微血管病变的形态发生]

[Morphogenesis of diabetic microangiopathy].

作者信息

Saltykov B B, Kaufman O Ia, Velikov V K, Shubina O I

出版信息

Arkh Patol. 1991;53(7):60-5.

PMID:1741670
Abstract

Skin biopsies from 40 patients 17 to 75 years old with type I and II diabetes mellitus were studied morphologically. The formation of diabetic microangiopathy starts with the damage of endotheliocytes, vascular permeability disturbance, activation of pericytes and smooth muscle elements with subsequent thickening of basal membranes and capillary and arteriole hyalinosis, these lesions being directly related to the duration of diabetes. Diabetic microangiopathy is a manifestation of the disease and its morphology is similar in both type I and II diabetes.

摘要

对40例年龄在17至75岁之间的I型和II型糖尿病患者的皮肤活检标本进行了形态学研究。糖尿病微血管病变的形成始于内皮细胞损伤、血管通透性紊乱、周细胞和平滑肌成分激活,随后基底膜增厚以及毛细血管和小动脉玻璃样变性,这些病变与糖尿病病程直接相关。糖尿病微血管病变是该疾病的一种表现,其形态在I型和II型糖尿病中相似。

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