Xu Hua-Tai, Pan Feng, Yang Guang, Gan Wen-Biao
Molecular Neurobiology Program, Skirball Institute, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.
Nat Neurosci. 2007 May;10(5):549-51. doi: 10.1038/nn1883. Epub 2007 Apr 8.
Determining the degree of synapse formation and elimination is essential for understanding the structural basis of brain plasticity and pathology. We show that in vivo imaging of dendritic spine dynamics through an open-skull glass window, but not a thinned-skull window, is associated with high spine turnover and substantial glial activation during the first month after surgery. These findings help to explain existing discrepancies in the degree of dendritic spine plasticity observed in the mature cortex.
确定突触形成和消除的程度对于理解大脑可塑性和病理学的结构基础至关重要。我们发现，通过开颅玻璃窗口而非薄颅窗口对树突棘动态进行体内成像，与术后第一个月内高树突棘更新率和大量胶质细胞激活有关。这些发现有助于解释在成熟皮层中观察到的树突棘可塑性程度方面现有的差异。
