Pidwell Diane J, Burns Carolyn
Department of Pathology, Jewish Hospital, Louisville, KY 40202, USA.
Clin Plast Surg. 2007 Apr;34(2):303-17, x. doi: 10.1016/j.cps.2006.12.002.
Composite tissue allotransplantation holds great potential for reconstructive surgery. That these procedures can be successful has been clearly demonstrated by the success of hand, face, and larynx transplants around the world. Although the immunology of composite tissue allotransplantation mirrors that of any allogeneic organ transplant, there are several unique aspects to these grafts. This article reviews the immunology of transplantation, histocompatibility testing for composite tissue allotransplantation, graft rejection, immunosuppression, and specific immunologic considerations of composite tissue allotransplantation.
复合组织异体移植在重建外科手术中具有巨大潜力。世界各地手、面部和喉部移植的成功已清楚地证明了这些手术能够取得成功。尽管复合组织异体移植的免疫学与任何同种异体器官移植的免疫学相似，但这些移植物有几个独特之处。本文综述了移植免疫学、复合组织异体移植的组织相容性检测、移植物排斥反应、免疫抑制以及复合组织异体移植的特定免疫学考虑因素。
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