Brumfield C G, Davis R O, Hauth J C, Cosper P, Colvin E V, Finley S C
Department of Obstetrics and Gynecology, University of Alabama, Birmingham.
Am J Perinatol. 1991 Jul;8(4):255-8. doi: 10.1055/s-2007-999391.
The pregnancy outcomes of 155 women who underwent an amniocentesis for a prenatal karyotype after being diagnosed by ultrasound as having one or more nonlethal structural anomalies are presented. Thirty-three (21%) patients were found to have an abnormal karyotype. Knowledge of the prenatal karyotype was useful in the subsequent management of these pregnancies. A pregnancy with a fetal anomaly diagnosed prior to 24 weeks was more likely to be terminated if an abnormal karyotype was also present. In women who were diagnosed as having a fetal anomaly with an abnormal karyotype at 24 weeks or later, only 3 of 13 (23%) infants survived the neonatal period. Knowledge of the karyotype results influenced decisions regarding the place, timing, and route of delivery in these fetuses. In 32 women, (21%) a karyotype was beneficial by avoiding maternal transport, cesarean delivery, and neonatal expenses at a Level III perinatal center.
本文介绍了155名孕妇的妊娠结局，这些孕妇经超声诊断有一个或多个非致死性结构异常后接受了羊水穿刺以进行产前核型分析。33名（21%）患者被发现有异常核型。产前核型的信息对这些妊娠的后续管理有用。如果同时存在异常核型，在24周前诊断出胎儿异常的妊娠更有可能被终止。在24周或更晚时被诊断为胎儿异常且核型异常的女性中，13名婴儿中只有3名（23%）存活至新生儿期。核型结果的信息影响了这些胎儿的分娩地点、时间和途径的决策。在32名（21%）女性中，核型分析通过避免产妇转运、剖宫产以及三级围产期中心的新生儿费用而有益。
