过去二十年日本前列腺癌患者的睾酮预处理总水平。
Pretreatment total testosterone levels in patients with prostate cancer in the past two decades in Japan.
作者信息
Sekine Yoshitaka, Ito Kazuto, Yamamoto Takumi, Nakazato Haruki, Shibata Yasuhiro, Hatori Motoaki, Suzuki Kazuhiro
机构信息
Department of Urology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma-pref 371-8511, Japan.
出版信息
Cancer Detect Prev. 2007;31(2):149-53. doi: 10.1016/j.cdp.2006.12.007. Epub 2007 Apr 6.
BACKGROUND
Many studies have shown the relationship between pretreatment serum testosterone levels and the clinical stage or histological grade, but the clinical significance of pretreatment testosterone levels is controversial. We studied the association of pretreatment total testosterone levels with the clinical stage and histological grade of prostate cancer.
METHODS
We evaluated 2914 patients whose pretreatment testosterone levels were recorded from 1982 to 2002. Serum testosterone levels were measured by radioimmunoassay.
RESULTS
There was a trend toward decreasing testosterone values with worsening clinical staging. There was a trend toward decreasing testosterone values with worsening histological grading, too. Patients with poorly differentiated adenocarcinoma had significantly lower testosterone levels than those with the others (versus well; p<0.01, moderately; p<0.01).
CONCLUSIONS
Newly diagnosed patients with poorly differentiated adenocarcinoma of prostate have lower testosterone levels than the others.
背景
许多研究已经表明治疗前血清睾酮水平与临床分期或组织学分级之间的关系，但治疗前睾酮水平的临床意义仍存在争议。我们研究了治疗前总睾酮水平与前列腺癌临床分期和组织学分级之间的关联。
方法
我们评估了2914例在1982年至2002年间记录了治疗前睾酮水平的患者。血清睾酮水平通过放射免疫测定法进行测量。
结果
随着临床分期的恶化，睾酮值有下降趋势。随着组织学分级的恶化，睾酮值也有下降趋势。低分化腺癌患者的睾酮水平明显低于其他患者（与高分化相比；p<0.01，中分化；p<0.01）。
结论
新诊断的前列腺低分化腺癌患者的睾酮水平低于其他患者。
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