Lukásová P, Vcelák J, Vanková M, Vejrazková D, Bendlová B
Endokrinologický ústav, Praha.
Cas Lek Cesk. 2007;146(3):227-34.
Recent molecular biological studies of the pancreatic development have shed new light on the cause of MODY and diabetes mellitus type 2. The identification of transcription factors participating in the regulatory networks cooperating in the development and in adult exocrine and endocrine pancreas enabled the better understanding of the genetic background and subsequent phenotypic features of diabetes.
近期关于胰腺发育的分子生物学研究为青少年发病的成年型糖尿病(MODY)和2型糖尿病的病因带来了新的见解。对参与胰腺发育以及成年外分泌和内分泌胰腺调控网络协同作用的转录因子的鉴定,有助于更好地理解糖尿病的遗传背景及后续表型特征。