Basto Renata, Pines Jonathon
Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR United Kingdom.
Dev Cell. 2007 Apr;12(4):475-7. doi: 10.1016/j.devcel.2007.03.012.
During mitosis, the interaction between chromosomes and microtubules requires nuclear envelope disassembly in prophase. Two articles in this issue of Developmental Cell show that centrosomes have a role in promoting nuclear envelope breakdown (Hachet et al., 2007; Portier et al., 2007). Surprisingly, the role of the centrosome in this process is independent of its role as a microtubule nucleation organelle. Instead, the centrosome seems to act as a spatial regulator for the activation of the Aurora A kinase.
在有丝分裂过程中，染色体与微管之间的相互作用需要在前期进行核膜解体。本期《发育细胞》中的两篇文章表明，中心体在促进核膜破裂中发挥作用（哈谢特等人，2007年；波捷等人，2007年）。令人惊讶的是，中心体在这个过程中的作用与其作为微管成核细胞器的作用无关。相反，中心体似乎作为Aurora A激酶激活的空间调节因子发挥作用。
