活性氧通过氧化还原敏感蛋白酶调节自噬。
Reactive oxygen species regulate autophagy through redox-sensitive proteases.
作者信息
Liu Zhihua, Lenardo Michael J
机构信息
Laboratory of Immunology, NIAID, NIH, Building 10, Room 11N311, 10 Center Drive, MSC 1892, Bethesda, MD 20892, USA.
出版信息
Dev Cell. 2007 Apr;12(4):484-5. doi: 10.1016/j.devcel.2007.03.016.
PMID:17419989
Abstract
Starvation induces autophagy through a signal transduction pathway that is not fully understood. In a recent issue of The EMBO Journal, Scherz-Shouval and colleagues (Scherz-Shouval et al., 2007) show that reactive oxygen species (ROS) occurring during starvation serve as signaling molecules that initiate autophagy.
摘要
饥饿通过一条尚未完全了解的信号转导途径诱导自噬。在最近一期的《欧洲分子生物学组织杂志》上，舍尔茨-舒瓦尔及其同事（舍尔茨-舒瓦尔等人，2007年）表明，饥饿期间产生的活性氧（ROS）作为启动自噬的信号分子。
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