Taioli Emanuela, Sram Radim J, Garte Seymour, Kalina Ivan, Popov Todor A, Farmer Peter B
University of Pittsburgh Cancer Institute, 5150 Centre Avenue, Pittsburgh, PA 15232, USA.
Mutat Res. 2007 Jul 1;620(1-2):1-6. doi: 10.1016/j.mrfmmm.2007.02.016. Epub 2007 Mar 3.
The EXPAH project was a molecular epidemiology study whose aims were to evaluate the hypothesis that polycyclic aromatic hydrocarbons (PAHs) are a major source of genotoxic activities of organic mixtures associated with air pollution. Biomarkers of exposure, effects and susceptibility, and oxidative DNA damage were measured in three PAH-exposed populations from Prague (Czech Republic), Kosice (Slovakia) and Sofia (Bulgaria). Control populations were included from each city. In total 356 individuals were enrolled. A questionnaire was used to determine life style/dietary factors. Ambient air exposure was measured by stationary monitoring, and personal exposure monitoring was also carried out. The characteristics of the population are described in this paper together with their personal exposure to carcinogenic PAHs (c-PAHs). The dose of c-PAH exposure was found to vary between the occupationally exposed (e.g. policemen and bus drivers) and the control populations in each country, and also varied from country to country.
EXPAH项目是一项分子流行病学研究，其目的是评估多环芳烃（PAHs）是与空气污染相关的有机混合物遗传毒性活性的主要来源这一假设。在来自布拉格（捷克共和国）、科希策（斯洛伐克）和索非亚（保加利亚）的三个接触PAH的人群中，测量了接触、效应和易感性的生物标志物以及氧化性DNA损伤。每个城市都纳入了对照人群。总共招募了356名个体。使用问卷来确定生活方式/饮食因素。通过固定监测来测量环境空气暴露，同时也进行了个人暴露监测。本文描述了人群的特征以及他们个人接触致癌多环芳烃（c-PAHs）的情况。发现每个国家职业接触人群（如警察和公交车司机）与对照人群之间的c-PAH暴露剂量有所不同，而且不同国家之间也存在差异。
