Vilema-Enríquez Gabriela, Arroyo Aurora, Grijalva Marcelo, Amador-Zafra Ricardo Israel, Camacho Javier
Departamento de Ciencias de la Vida, Universidad de las Fuerzas Armadas (ESPE), Avenida General Rumiñahui, S/N, P.O. Box 171-5-231B, Sangolquí, Ecuador; Centro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas (ESPE), Avenida General Rumiñahui, S/N, P.O. Box 171-5-231B, Sangolquí, Ecuador; Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK.
Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico.
Oxid Med Cell Longev. 2016;2016:1908164. doi: 10.1155/2016/1908164. Epub 2016 Jun 8.
Lung cancer has a very high mortality-to-incidence ratio, representing one of the main causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently needed. Several diseases including lung cancer have been associated with the action of reactive oxygen species (ROS) from which hydrogen peroxide (H2O2) is one of the most studied. Despite the fact that H2O2 may have opposite effects on cell proliferation depending on the concentration and cell type, it triggers several antiproliferative responses. H2O2 produces both nuclear and mitochondrial DNA lesions, increases the expression of cell adhesion molecules, and increases p53 activity and other transcription factors orchestrating cancer cell death. In addition, H2O2 facilitates the endocytosis of oligonucleotides, affects membrane proteins, induces calcium release, and decreases cancer cell migration and invasion. Furthermore, the MAPK pathway and the expression of genes related to inflammation including interleukins, TNF-α, and NF-κB are also affected by H2O2. Herein, we will summarize the main effects of hydrogen peroxide on human lung cancer leading to suggesting it as a potential therapeutic tool to fight this disease. Because of the multimechanistic nature of this molecule, novel therapeutic approaches for lung cancer based on the use of H2O2 may help to decrease the mortality from this malignancy.
肺癌具有很高的死亡率与发病率之比，是全球癌症死亡的主要原因之一。因此，迫切需要新的治疗策略。包括肺癌在内的几种疾病都与活性氧（ROS）的作用有关，其中过氧化氢（H2O2）是研究最多的一种。尽管H2O2根据浓度和细胞类型可能对细胞增殖产生相反的影响，但它会引发多种抗增殖反应。H2O2会导致细胞核和线粒体DNA损伤，增加细胞粘附分子的表达，并增加p53活性以及其他协调癌细胞死亡的转录因子。此外，H2O2促进寡核苷酸的内吞作用，影响膜蛋白，诱导钙释放，并降低癌细胞的迁移和侵袭能力。此外，丝裂原活化蛋白激酶（MAPK）途径以及与炎症相关的基因（包括白细胞介素、肿瘤坏死因子-α和核因子κB）的表达也受到H2O2的影响。在此，我们将总结过氧化氢对人类肺癌的主要影响，从而表明它是对抗这种疾病的一种潜在治疗工具。由于该分子具有多机制性质，基于使用H2O2的肺癌新型治疗方法可能有助于降低这种恶性肿瘤的死亡率。
