Fazilleau Nicolas, McHeyzer-Williams Louise J, McHeyzer-Williams Michael G
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Curr Opin Immunol. 2007 Jun;19(3):259-67. doi: 10.1016/j.coi.2007.04.003. Epub 2007 Apr 8.
Clonal evolution underpins all facets of adaptive immunity. In particular, antigen-specific helper T (Th) cell development is central to high-affinity B cell immunity and protective vaccination. Dendritic cell maturation and TCR affinity-based selection mechanisms control the recruitment and effective propagation of preferred antigen-specific Th cell cohorts in local lymphoid tissue. Importantly, follicular B helper T (T(FH)) cells emerge as the specialized local effector Th cells that orchestrate the stepwise development of B cell immunity in these local environments. Recent studies also introduce the role of persistent antigen in the development of effector Th cells with evidence for long-term antigen depots that might contribute to local antigen-specific Th cell memory.
克隆进化是适应性免疫各个方面的基础。特别是，抗原特异性辅助性T（Th）细胞的发育对于高亲和力B细胞免疫和保护性疫苗接种至关重要。树突状细胞成熟和基于TCR亲和力的选择机制控制着局部淋巴组织中优选的抗原特异性Th细胞群体的募集和有效增殖。重要的是，滤泡性B辅助性T（T(FH)）细胞作为专门的局部效应Th细胞出现，它们在这些局部环境中协调B细胞免疫的逐步发展。最近的研究还介绍了持续性抗原在效应Th细胞发育中的作用，有证据表明长期抗原库可能有助于局部抗原特异性Th细胞记忆。
