Hinken Aaron C, Solaro R John
Department of Physiology and Biophysics and Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, IL, USA.
Physiology (Bethesda). 2007 Apr;22:73-80. doi: 10.1152/physiol.00043.2006.
Molecular motors housed in myosins of the thick filament react with thin-filament actins and promote force and shortening in the sarcomeres. However, other actions of these motors sustain sarcomeric activation by cooperative feedback mechanisms in which the actin-myosin interaction promotes thin-filament activation. Mechanical feedback also affects the actin-myosin interaction. We discuss current concepts of how these relatively under-appreciated actions of molecular motors are responsible for modulation of the ejection time and isovolumic relaxation in the beating heart.
粗肌丝肌球蛋白中的分子马达与细肌丝肌动蛋白发生反应，并促进肌节中的力产生和缩短。然而，这些马达的其他作用通过协同反馈机制维持肌节激活，在该机制中，肌动蛋白 - 肌球蛋白相互作用促进细肌丝激活。机械反馈也会影响肌动蛋白 - 肌球蛋白相互作用。我们讨论了关于分子马达这些相对未被充分认识的作用如何调节跳动心脏的射血时间和等容舒张的当前概念。
