氯霉素在牛体内的生物利用度：随注射部位数量和药物制剂浓度的变化
Bioavailability of chloramphenicol in cattle: variation with the number of injection sites and the concentration of the pharmaceutical preparation.
作者信息
Lamothe P, Panisset J C, Malo R, Couture Y
出版信息
Can Vet J. 1982 Sep;23(9):269-71.
Abstract
A bioavailability study of three commercial chloramphenicol preparations was carried out in cattle in order to determine the influence of the number of muscular injection sites and the concentration of the product on the level of chloramphenicol serum concentration. Results show that chloramphenicol should be injected at the dose of 22 mg/kg at multiple injection sites to reach 5 mug/mL of serum which is considered to be the minimal inhibitory concentration.
摘要
为了确定肌肉注射部位数量和产品浓度对氯霉素血清浓度水平的影响，对三种市售氯霉素制剂进行了牛的生物利用度研究。结果表明，氯霉素应以22毫克/千克的剂量在多个注射部位注射，以达到5微克/毫升的血清浓度，这被认为是最低抑菌浓度。
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本文引用的文献
1
Pharmacokinetics, plasma protein binding and dosage of chloramphenicol in cattle and horses.氯霉素在牛和马体内的药代动力学、血浆蛋白结合情况及剂量
Res Vet Sci. 1973 Sep;15(2):231-8.
2
Chloramphenicol concentrations in blood and milk of cows following parenteral administration.奶牛经肠胃外给药后血液和乳汁中的氯霉素浓度。
Can Vet J. 1973 Sep;14(9):217-20.
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A pharmacologic study of chloramphenicol in cattle.
Am J Vet Res. 1973 Sep;34(9):1147-51.
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Clinical uses of chloramphenicol.氯霉素的临床用途。
Mod Vet Pract. 1978 Dec;59(12):889-94.
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