三种四环素类药物制剂肌肉注射后犊牛血清药物水平的研究。
Study of serum drug levels in calves following intramuscular administration of three tetracycline drug preparations.
作者信息
Black W D, Claxton J, Robinson G A
出版信息
Can Vet J. 1982 Oct;23(10):296-8.
Three antibiotic formulations, oxytetracycline (A) in propylene glycol and oxytetracycline (B) in polyvinyl pyrrolidine and pyrrolidino-methyltetracycline in an oil suspension were given to calves by the intramuscular route. Only oxytetracycline (A) appeared to cause much pain after injection.The half-time elimination (t((1/2)cl)) for oxytetracycline (A) was 14.000 +/- 3.580 h for oxytetracycline (B) 10.290 +/-5.159 h and for pyrrolidinomethyltetracycline 8.160 +/- 0.920 h. The rate of elimination ;beta slope" for oxytetracycline (A) was 0.052 +/- 0.012 h(-1) for oxytetracycline (B) 0.077 +/- 0.261 h(-1) and for pyrrolidinomethyltetracycline 0.086 +/- 0.010 h(-1). The Y intercept of the "beta" elimination slope C(os) (mug/mL) for oxytetracycline (A) was 2.490 +/- 1.040, for oxytetracycline (B) 3.463 +/- 1.874 and for pyrrolidinomethyltetracycline 2.852 +/- 1.360.Pyrrolidinomethyltetracycline appeared to have a two component elimination curve, however, only the "beta slope" was used for the calculations.
三种抗生素制剂，即丙二醇中的土霉素（A）、聚乙烯吡咯烷酮中的土霉素（B）以及油悬液中的吡咯烷甲基四环素，通过肌肉注射给予小牛。只有土霉素（A）在注射后似乎引起较多疼痛。土霉素（A）的消除半衰期（t((1/2)cl)）为14.000±3.580小时，土霉素（B）为10.290±5.159小时，吡咯烷甲基四环素为8.160±0.920小时。土霉素（A）的消除速率“β斜率”为0.052±0.012 h⁻¹，土霉素（B）为0.077±0.261 h⁻¹，吡咯烷甲基四环素为0.086±0.010 h⁻¹。土霉素（A）的“β”消除斜率的Y轴截距C(os)（μg/mL）为2.490±1.040，土霉素（B）为3.463±1.874，吡咯烷甲基四环素为2.852±1.360。吡咯烷甲基四环素似乎有一条双组分消除曲线，然而，计算仅使用“β斜率”。
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