Gifford G A, Potter A A, Babiuk L A
Can Vet J. 1988 Feb;29(2):142-8.
An experiment was conducted to evaluate the efficacy of sulbactam/ampicillin for treatment of bovine pneumonic pasteurellosis. Twenty-one Hereford calves were experimentally infected with bovine herpesvirus-1 and an ampicillin-resistant strain of Pasteurella haemolytica, then treated for three days with either sulbactam/ampicillin, chloramphenicol, or a placebo. The treatments were evaluated by comparing clinical illness scores, total sick days, weight changes, mortality rates, and postmortem lung scores between treatment groups. Both antibiotics were highly effective in reducing respiratory disease in the experimentally infected calves. The clinical response to sulbactam/ampicillin treatment was comparable with that of chloramphenicol and was significantly improved compared with the response to the placebo treatment. These findings suggest that the efficacy of sulbactam/ampicillin may be comparable to that of chloramphenicol for treatment of pneumonic pasteurellosis involving ampicillin-resistant strains of P. haemolytica.
进行了一项实验以评估舒巴坦/氨苄西林治疗牛肺炎性巴氏杆菌病的疗效。选用21头赫里福德犊牛，用牛疱疹病毒1型和一株对氨苄西林耐药的溶血巴氏杆菌进行实验性感染，然后分别用舒巴坦/氨苄西林、氯霉素或安慰剂治疗三天。通过比较各治疗组之间的临床疾病评分、总患病天数、体重变化、死亡率和死后肺脏评分来评估治疗效果。两种抗生素在降低实验感染犊牛的呼吸道疾病方面都非常有效。舒巴坦/氨苄西林治疗的临床反应与氯霉素相当，与安慰剂治疗相比有显著改善。这些发现表明，对于治疗由对氨苄西林耐药的溶血巴氏杆菌菌株引起的肺炎性巴氏杆菌病，舒巴坦/氨苄西林的疗效可能与氯霉素相当。
