Yates W D, Babiuk L A, Jericho K W
Can J Comp Med. 1983 Jul;47(3):257-64.
Sixteen six to eight month old beef calves were exposed individually to a five minute aerosol of bovine herpesvirus 1, isolate 108. Aerosol exposure to Pasteurella haemolytica (biotype A, serotype 1) was administered individually for five minutes at either four, ten, 20 or 30 days after the virus. Fibrinous pneumonia and pleuritis occurred in all four groups but were most extensive and severe in those exposed to the virus and bacterium four days apart (the positive controls). Fibrinous pneumonia was associated with persistence of bovine herpesvirus 1 in the respiratory tract despite resolution of virus-induced necrotic lesions of the respiratory mucosa. The results presented here suggest that, although the severity of viral-bacterial synergism may be influenced by virus-induced morphological changes, the continued presence of viral antigens after the resolution of respiratory mucosal lesions may continue to exert some effect on host defenses and disease processes.
16头6至8月龄的肉用犊牛分别暴露于牛疱疹病毒1型（分离株108）的5分钟气雾剂中。在感染病毒后的第4、10、20或30天，分别对犊牛进行5分钟的溶血性巴氏杆菌（生物型A，血清型1）气雾剂暴露。所有四组均出现了纤维素性肺炎和胸膜炎，但在病毒感染和细菌暴露间隔4天的组中（阳性对照组）最为广泛和严重。尽管呼吸道黏膜的病毒诱导坏死性病变已经消退，但纤维素性肺炎与呼吸道中牛疱疹病毒1的持续存在有关。此处呈现的结果表明，虽然病毒 - 细菌协同作用的严重程度可能受病毒诱导的形态学变化影响，但呼吸道黏膜病变消退后病毒抗原的持续存在可能会继续对宿主防御和疾病进程产生一些影响。
