Sakka M, Katsuta H, Takaoka T
Tohoku J Exp Med. 1975 Dec;117(4):299-309. doi: 10.1620/tjem.117.299.
The time of cell destruction was determined by pedigree analysis before macrocolony formation immediately after irradiation of gamma rays (400-900 R) in cultured rat hepatoma cells. Cell destruction occurred and was distributed to various generations in proportion to dose. The loss of reproductive integrity resulting in an extinction of a clone was limited in earlier generations, 0 to 2, but the loss of reproductive capacity was observed in later generations. It seems probable that two types of loss of reproduction come from random transmission of lethal signals produced in parent cells irrespective of the pattern of pedigrees.
通过谱系分析确定了培养的大鼠肝癌细胞在γ射线（400 - 900伦琴）照射后立即形成大菌落之前的细胞破坏时间。细胞破坏发生，并与剂量成比例地分布到不同代次。导致克隆灭绝的生殖完整性丧失在早期代次（0至2代）中是有限的，但在后期代次中观察到了生殖能力的丧失。似乎两种生殖能力的丧失可能来自亲代细胞中产生的致死信号的随机传递，而与谱系模式无关。
