Establishment of a nationalized, multiregional Paired Donation Network.

Over the past few years, significant progress has been made in the science and development of paired donation. With increasing awareness of paired donation and ready availability of the tools necessary to establish new consortia, paired donation can be made available to transplant programs and patients with increasing alacrity. Increasing registration of recipients and their donors for paired donation will lead to larger pools for matching and to transplantation of increasing numbers of patients via paired donation. As paired donation becomes common practice throughout the US and the international transplant community, its role in facilitating transplantation of sensitized patients will be better defined. Presently, paired donation remains an attractive alternative to desensitization and wait list paired donation for a majority of patients with preexisting humoral immunity to their donors.