Klostermann Fabian, Nikulin Vadim V, Kühn Andrea Annette, Marzinzik Frank, Wahl Michael, Pogosyan Alek, Kupsch Andreas, Schneider Gerd-Helge, Brown Peter, Curio Gabriel
Department of Neurology, CBF/CVK, Charité-University Medicine Berlin, Berlin, Germany.
Eur J Neurosci. 2007 Mar;25(5):1604-15. doi: 10.1111/j.1460-9568.2007.05417.x.
Movement-related processing results in the modulation of neuronal synchronization over several electroencephalography (EEG) frequency ranges, including alpha- (8-12 Hz) and beta-band (14-30 Hz). Whether modulation patterns differ across sites within the motor system remains unclear, but could denote how information is conveyed across the cortico-basal network. We therefore compared the event-related synchronization/desynchronization (ERS/ERD) in recordings from the scalp, basal ganglia and thalamic structures during a motor task. Simultaneous depth and scalp EEG were recorded in 13 patients, undergoing deep brain stimulation of the thalamic ventral intermediate nucleus (VIM) or the subthalamic nucleus (STN). They performed a choice-reaction task with pre-cued Go-signals, instructive for either left- or right-sided button presses. In the beta-band, pre-cues and Go-signals were followed by ERD starting well before and peaking at task execution, uniformly in all cortical and subcortical recordings. In contrast, a comparable alpha-band ERD was only seen at the scalp, whereas mirror-like ERS were observed in the motor-inhibitory STN. In VIM, which receives strong somatosensory afferences, a major alpha-ERD upon the Go-signal did not start until the motor response. These dissociations of task-related Alpha- and Beta-band dynamics tag a functional diversity in cortico-basal networks, which are simultaneously active in motor processing. Whereas the uniform downregulation of Beta-activity points to an anti-kinetic operation mode throughout the motor system, site-dependent courses of Alpha-synchronization rather reflect the coordination of activity levels in functionally divergent motor structures during the preparation and execution of movements.
与运动相关的处理会导致在多个脑电图（EEG）频率范围内对神经元同步进行调制，包括阿尔法频段（8 - 12赫兹）和贝塔频段（14 - 30赫兹）。运动系统内不同部位的调制模式是否存在差异尚不清楚，但这可能表明信息是如何在皮质 - 基底网络中传递的。因此，我们比较了运动任务期间头皮、基底神经节和丘脑结构记录中的事件相关同步/去同步（ERS/ERD）情况。对13名接受丘脑腹中间核（VIM）或丘脑底核（STN）深部脑刺激的患者同时进行深部和头皮EEG记录。他们执行了一个带有预提示“开始”信号的选择反应任务，该信号指示向左或向右按压按钮。在贝塔频段，预提示和“开始”信号之后均跟随有ERD，在所有皮质和皮质下记录中，ERD均在任务执行前很早就开始并在任务执行时达到峰值。相比之下，类似的阿尔法频段ERD仅在头皮处可见，而在运动抑制性的STN中观察到镜像样的ERS。在接受强烈体感传入的VIM中，“开始”信号后的主要阿尔法ERD直到运动反应时才开始。任务相关的阿尔法和贝塔频段动态变化的这些分离标记了皮质 - 基底网络中的功能多样性，这些网络在运动处理过程中同时处于活跃状态。虽然贝塔活动的均匀下调表明整个运动系统存在抗运动操作模式，但阿尔法同步的部位依赖性过程更能反映在运动准备和执行过程中功能不同的运动结构中活动水平的协调情况。
