Yoshitake H, Takahashi M, Ishikawa H, Nojima M, Iwanari H, Watanabe A, Aburatani H, Yoshida K, Ishi K, Takamori K, Ogawa H, Hamakubo T, Kodama T, Araki Y
Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan.
Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1300-6. doi: 10.1111/j.1525-1438.2007.00932.x. Epub 2007 Apr 9.
Aldo-keto reductase family 1, member B10 (AKR1B10), an enzyme that converts retinals into retinols is known to detect in non-small cell lung carcinoma (squamous cell- and adeno-carcinomas), but is barely expressed in normal tissues. Since these types of carcinoma occur frequently in the uterus (like in the lung), AKR1B10 may also be overexpressed in two major types of uterine cancer, cervical cancer (CC), and endometrial cancer (EMC). The objective of this study is to investigate AKR1B10 expression in uterine cancer and to analyze its clinical significance. In samples from uterine cancer patients, AKR1B10 was detected in 6 out of 30 (20.0%) CC cases and 6 out of 38 (15.8%) EMC cases. Statistical analysis indicated that AKR1B10 expression was associated with tumor recurrence after surgery and keratinization of squamous cell carcinoma only in CC. Although retinol (a metabolic product by AKR1B10) was observed in the normal epithelium, the molecule was not observed in cancer cells of AKR1B10-positive CC samples suggesting that the recurrence in CC may not depend on the convert of retinals into retinols via AKR1B10, a potential indicator in the management of patients with CC.
醛酮还原酶家族1成员B10（AKR1B10）是一种将视黄醛转化为视黄醇的酶，已知在非小细胞肺癌（鳞状细胞癌和腺癌）中可检测到，但在正常组织中几乎不表达。由于这些类型的癌症在子宫中也经常发生（与在肺部一样），AKR1B10在子宫颈癌（CC）和子宫内膜癌（EMC）这两种主要类型的子宫癌中也可能过表达。本研究的目的是调查AKR1B10在子宫癌中的表达情况，并分析其临床意义。在子宫癌患者的样本中，30例CC病例中有6例（20.0%）检测到AKR1B10，38例EMC病例中有6例（15.8%）检测到AKR1B10。统计分析表明，AKR1B10的表达仅在CC中与术后肿瘤复发和鳞状细胞癌的角化有关。虽然在正常上皮中观察到视黄醇（AKR1B10的一种代谢产物），但在AKR1B10阳性CC样本的癌细胞中未观察到该分子，这表明CC中的复发可能不依赖于通过AKR1B10将视黄醛转化为视黄醇，AKR1B10是CC患者管理中的一个潜在指标。
