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尿道疼痛综合征及其治疗

Urethral pain syndrome and its management.

作者信息

Kaur Hervinder, Arunkalaivanan Angamuthu S

机构信息

North Staffordshire University Hospital, Stoke-on-Trent, United Kingdom.

出版信息

Obstet Gynecol Surv. 2007 May;62(5):348-51; quiz 353-4. doi: 10.1097/01.ogx.0000261645.12099.2a.

DOI:10.1097/01.ogx.0000261645.12099.2a
PMID:17425813
Abstract

UNLABELLED

Urethral pain syndrome is occurrence of persistent or recurrent episodic urethral pain usually on voiding with daytime frequency and nocturia, in the absence of proven infection or other obvious pathology. This is a condition of uncertain etiology. The objective of this article is to review etiology, diagnosis, and management of urethral pain syndrome. Since there is paucity of information on randomized trials, search of published literature has been made using keywords such as "urethral pain syndrome", "painful bladder syndrome", "urethral stenosis", and "lower urinary tract symptoms". Urethral pain syndrome is a disease of ambiguous etiology. Diagnosis is mainly based upon symptoms, and investigations are aimed to exclude other conditions affecting lower urinary tract. Various modalities of treatment including antibiotics, alpha-blockers, acupuncture, and laser therapy have been proved successful. Psychological support is very important in this group of women. Management requires multidisciplinary approach, and treatment at its best is by trial and error.

TARGET AUDIENCE

Obstetricians & Gynecologists, Family Physicians.

LEARNING OBJECTIVES

After completion of this article, the reader should be able to explain that the urethral pain syndrome (UPS) has specific signs and symptoms without specific responses to a variety of treatment options and recall that treatment may require a multidisciplinary approach and a lot of sensitivity by the physician.

摘要

未标注

尿道疼痛综合征是指在无已证实的感染或其他明显病理状况下,通常在排尿时出现持续或反复发作的尿道疼痛,并伴有白天尿频和夜尿症。这是一种病因不明的病症。本文的目的是综述尿道疼痛综合征的病因、诊断和治疗。由于关于随机试验的信息匮乏,我们使用了“尿道疼痛综合征”、“膀胱疼痛综合征”、“尿道狭窄”和“下尿路症状”等关键词在已发表的文献中进行检索。尿道疼痛综合征是一种病因不明的疾病。诊断主要基于症状,检查旨在排除影响下尿路的其他病症。包括抗生素、α受体阻滞剂、针灸和激光治疗在内的各种治疗方式已被证明是有效的。心理支持在这组女性患者中非常重要。治疗需要多学科方法,最佳治疗方式是反复试验。

目标受众

妇产科医生、家庭医生。

学习目标

阅读本文后,读者应能够解释尿道疼痛综合征(UPS)有特定的体征和症状,对多种治疗选择无特定反应,并记住治疗可能需要多学科方法,且医生要有高度的敏感性。

相似文献

1
Urethral pain syndrome and its management.尿道疼痛综合征及其治疗
Obstet Gynecol Surv. 2007 May;62(5):348-51; quiz 353-4. doi: 10.1097/01.ogx.0000261645.12099.2a.
2
[Urethral pain syndrome: fact or fiction--an update].[尿道疼痛综合征:事实还是虚构——最新进展]
Urologe A. 2015 Sep;54(9):1248-55. doi: 10.1007/s00120-015-3926-9.
3
The urethral syndrome.尿道综合征
Urol Clin North Am. 1988 Nov;15(4):699-704.
4
Treatment of female urethral syndrome refractory to antibiotics.抗生素治疗无效的女性尿道综合征的治疗
Yonsei Med J. 2002 Oct;43(5):644-51. doi: 10.3349/ymj.2002.43.5.644.
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Enigma of urethral pain syndrome: why are there so many ascribed etiologies and therapeutic approaches?尿道疼痛综合征之谜:为何有如此多的病因及治疗方法?
Int J Urol. 2014 Jun;21(6):544-8. doi: 10.1111/iju.12396. Epub 2014 Jan 21.
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[Study of the structure and microflora of urethral tissues in urethral pain syndrome].[尿道疼痛综合征中尿道组织的结构与微生物群研究]
Urologiia. 2021 Nov(5):41-49.
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The urethral syndrome.
Urol Clin North Am. 1985 May;12(2):349-54.
8
Urinary urgency and frequency, and chronic urethral and/or pelvic pain in females. Can doxycycline help?女性的尿急、尿频以及慢性尿道和/或盆腔疼痛。强力霉素会有帮助吗?
J Urol. 2004 Jul;172(1):232-5. doi: 10.1097/01.ju.0000128698.93305.2e.
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Female urethral diverticula.女性尿道憩室
Best Pract Res Clin Obstet Gynaecol. 2005 Dec;19(6):875-93. doi: 10.1016/j.bpobgyn.2005.08.008. Epub 2005 Sep 19.
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Female urethral syndrome. A female prostatitis?女性尿道综合征。一种女性前列腺炎?
West J Med. 1996 May;164(5):435-8.

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J Lasers Med Sci. 2024 Dec 17;15:e62. doi: 10.34172/jlms.2024.62. eCollection 2024.
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Diagnosis and treatment outcomes of urethritis-like symptoms in young males: a retrospective cohort study.年轻男性尿道刺激症状的诊断和治疗效果:一项回顾性队列研究。
Sci Rep. 2023 Oct 14;13(1):17469. doi: 10.1038/s41598-023-44733-z.
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Female chronic posterior urethritis is underestimated in patients with lower urinary tract symptoms.
女性慢性后尿道炎在有下尿路症状的患者中被低估了。
Transl Androl Urol. 2021 Aug;10(8):3456-3464. doi: 10.21037/tau-21-550.
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New Approaches in the Study of the Pathogenesis of Urethral Pain Syndrome.尿道疼痛综合征发病机制研究的新方法
Diagnostics (Basel). 2020 Oct 22;10(11):860. doi: 10.3390/diagnostics10110860.
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Treatment of Urethral Pain Syndrome (UPS) in Sweden.瑞典的尿道疼痛综合征(UPS)治疗方法。
PLoS One. 2019 Nov 22;14(11):e0225404. doi: 10.1371/journal.pone.0225404. eCollection 2019.
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Efficacy of sertraline and gabapentin in the treatment of urethral pain syndrome: retrospective results of a single institutional cohort.舍曲林和加巴喷丁治疗尿道疼痛综合征的疗效:单机构队列的回顾性结果
Cent European J Urol. 2018;71(1):78-83. doi: 10.5173/ceju.2018.1574. Epub 2017 Jan 16.
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Fundamentals and clinical perspective of urethral sphincter instability as a contributing factor in patients with lower urinary tract dysfunction--ICI-RS 2014.尿道括约肌功能不全作为下尿路功能障碍患者的一个促成因素的基础及临床观点——国际尿控学会2014年研讨会
Neurourol Urodyn. 2016 Feb;35(2):318-23. doi: 10.1002/nau.22815.
8
[Urethral pain syndrome: fact or fiction--an update].[尿道疼痛综合征:事实还是虚构——最新进展]
Urologe A. 2015 Sep;54(9):1248-55. doi: 10.1007/s00120-015-3926-9.
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Urothelial mucosal signaling and the overactive bladder-ICI-RS 2013.尿路上皮黏膜信号传导与膀胱过度活动症——2013年国际尿控学会研究研讨会
Neurourol Urodyn. 2014 Jun;33(5):597-601. doi: 10.1002/nau.22604. Epub 2014 May 16.