Klupińska Grazyna, Poplawski Tomasz, Drzewoski Józef, Harasiuk Agnieszka, Reiter Russel J, Blasiak Janusz, Chojnacki Jan
Department of Gastroenterology and Internal Medicine, Medical University of Lodz, Lodz, Poland.
J Clin Gastroenterol. 2007 Mar;41(3):270-4. doi: 10.1097/MCG.0b013e318031457a.
Melatonin may inhibit reactive oxygen species-related pathogenesis in the alimentary tract by neutralizing free radicals. In the present study we assessed the potential protective action of melatonin in ulcerlike dyspepsia.
Sixty patients aged 19 to 39 years with the diagnosis of functional dyspepsia according to the Rome Criteria II and no Helicobacter pylori infection were involved in the study. Melatonin, at a dose of 5 mg (n=30), or placebo (n=30) were taken in the evening for a period of 12 weeks. At this time, patients were on an equivalent diet and were only to take an alkaline drug in case of the abdominal pain.
After 12 weeks, the dyspeptic symptoms completely subsided in 17 patients in the melatonin-treatment group (56.6%). In other 9 individuals (30.0%) a partial improvement in health was achieved, especially in the frequency and intensity of nocturnal pain. After placebo, the majority of patients (93.3%) did not experience any improvement in symptoms. Multivariate analysis indicated that melatonin (odds ratio 95.86, 95% confidence interval 3.72-2469.37, P<0.01) correlated independently with significantly improved patients health. H. pylori past infection decreased positive effect of melatonin in ulcerlike dyspepsia.
Melatonin can be considered as an auxiliary drug in the treatment of ulcerlike dyspepsia.
褪黑素可通过中和自由基抑制胃肠道中与活性氧相关的发病机制。在本研究中，我们评估了褪黑素对溃疡样消化不良的潜在保护作用。
60名年龄在19至39岁之间、根据罗马标准II诊断为功能性消化不良且无幽门螺杆菌感染的患者参与了本研究。褪黑素组（n = 30）服用5毫克剂量的褪黑素，安慰剂组（n = 30）服用安慰剂，均在晚上服用，为期12周。在此期间，患者饮食相同，仅在腹痛时服用碱性药物。
12周后，褪黑素治疗组有17名患者（56.6%）的消化不良症状完全消退。另外9名患者（30.0%）病情部分改善，尤其是夜间疼痛的频率和强度。服用安慰剂后，大多数患者（93.3%）症状未改善。多因素分析表明，褪黑素（优势比95.86，95%置信区间3.72 - 2469.37，P < 0.01）与患者健康状况的显著改善独立相关。既往幽门螺杆菌感染会降低褪黑素对溃疡样消化不良的积极作用。
褪黑素可被视为治疗溃疡样消化不良的辅助药物。
