Kawagoe Takashi, Tamura Ryoi, Uwano Teruko, Asahi Takashi, Nishijo Hisao, Eifuku Satoshi, Ono Taketoshi
Department of Integrative Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Neuroreport. 2007 May 7;18(7):683-8. doi: 10.1097/WNR.0b013e3280bef9a6.
Neural activity was recorded from the mediodorsal thalamic nucleus of behaving rats during the discrimination of olfactory cues associated with or without a reward. Approximately 10% of mediodorsal thalamic neurons showed significant responses during the presentation of cues. Most of these neurons responded strongly to cues associated with a reward. These neurons also differentiated between cues, even in the same reinforcement (reward/nonreward) group. All of the neurons tested in extinction, relearning, and/or new-learning trials changed their responses flexibly according to the reward contingency. These neurons were located primarily in the central and medial segments of the mediodorsal thalamus. These results suggest that these mediodorsal thalamic neurons are the neural substrates for association learning of olfactory stimuli with rewards.
在行为大鼠辨别与奖励相关或无关的嗅觉线索期间，记录其丘脑背内侧核的神经活动。在呈现线索时，约10%的丘脑背内侧核神经元表现出显著反应。这些神经元中的大多数对与奖励相关的线索反应强烈。即使在同一强化（奖励/无奖励）组中，这些神经元也能区分不同线索。在消退、重新学习和/或新学习试验中测试的所有神经元都根据奖励条件灵活改变其反应。这些神经元主要位于丘脑背内侧核的中央和内侧部分。这些结果表明，这些丘脑背内侧核神经元是嗅觉刺激与奖励关联学习的神经基础。
