Korzeniewska Aleksandra, Sołoniewicz Anna, Stelmach Piotr, Sobocińska Agnieszka, Stelmach Iwona
Oddział Kliniczny Interny Dzieciecej i Alergologii III Katedry Pediatrii Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi, Poland.
Pneumonol Alergol Pol. 2006;74(4):372-6.
Recent studies have emphasied the role of eosinophils and it's metabolites in the pathogenesis of lung disease in cystic fibrosis. This study was designed to assess the relationship between serum and sputum ECP levels and clinical status of cystic fibrosis patients.
30 patients, aged 6-30 with moderate cystic fibrosis were recruited. Spirometry, weight and high, and Shwachman-Kulczycki score were measured, and serum and sputum samples were obtained for measurements of the eosinophil cationic protein (ECP).
We observed significant inverse correlation between sputum ECP levels and BMI (p<0.001) and FEV1 (p<0.001), and not significant inverse correlation between sputum ECP levels Shwachman-Kulczycki score (p=0.057). There was no signifi cant correlation between sputum ECP levels and FEF25/75% and between serum ECP levels and measured clinical parameters.
Results of this study suggest influence of eosinophil inflammation in respiratory tract on clinical status of CF patients.
近期研究强调了嗜酸性粒细胞及其代谢产物在囊性纤维化肺病发病机制中的作用。本研究旨在评估囊性纤维化患者血清和痰液嗜酸性粒细胞阳离子蛋白（ECP）水平与临床状况之间的关系。
招募了30名年龄在6至30岁之间的中度囊性纤维化患者。测量了肺活量、身高和体重以及施瓦赫曼-库尔茨基评分，并采集血清和痰液样本以测量嗜酸性粒细胞阳离子蛋白（ECP）。
我们观察到痰液ECP水平与体重指数（p<0.001）和第1秒用力呼气容积（FEV1）（p<0.001）之间存在显著负相关，而痰液ECP水平与施瓦赫曼-库尔茨基评分之间存在不显著的负相关（p=0.057）。痰液ECP水平与用力呼出25%至75%肺活量时的平均呼气流量（FEF25/75%）之间以及血清ECP水平与所测量的临床参数之间均无显著相关性。
本研究结果提示呼吸道嗜酸性粒细胞炎症对囊性纤维化患者临床状况有影响。
