Tworek Damian, Bocheńska-Marciniak Małgorzata, Kupczyk Maciej, Kupryś-Lipińska Izabela, Kuna Piotr
Klinika Chorób Wewnetrznych, Astmy i Alergii, Łodzi, Poland.
Pneumonol Alergol Pol. 2006;74(4):391-5.
The measurements of exhaled nitric oxide (eNO) are simple and useful method of assessment of inflammation in asthmatics' airways. One of the causes of its limited application in clinical practice is a number of factors influencing the results of measurements. The aim of the study was to determine the usefulness of eNO measurements in assessing the inflammation in a heterogeneous, in relation to atopic and smoking status, group of patients.
120 subjects suspected of having asthma participated in this study. During 2 weeks the patients noted daily asthma symptoms and daily use of rescue medication. After 14 days health related quality of life (HRQL) was determined by means of Asthma Quality of Life Questionnaire (AQLQ), eNO levels were measured and airways reversibility test was performed.
Preliminary diagnosis of asthma was confirmed in 84 patients on the basis of positive result of airways reversibility test. Among them, 21 subjects (25%) were smokers and 60 (71.4%) were atopic. No correlation was found between eNO and daily asthma symptom score, daily use of rescue medication, percent of airway reversibility after beta2-agonist and HRQL.
eNO measurements in a heterogeneous, in relation to atopic and smoking status, group of patients are of limited value in clinical assessment of asthma activity.
呼出一氧化氮（eNO）测量是评估哮喘患者气道炎症的一种简单且有用的方法。其在临床实践中应用受限的原因之一是多种因素会影响测量结果。本研究的目的是确定在一组与特应性和吸烟状况相关的异质性患者中，eNO测量在评估炎症方面的实用性。
120名疑似哮喘患者参与了本研究。在两周时间里，患者记录每日哮喘症状及每日急救药物的使用情况。14天后，通过哮喘生活质量问卷（AQLQ）确定健康相关生活质量（HRQL），测量eNO水平并进行气道可逆性测试。
根据气道可逆性测试阳性结果，84例患者确诊为哮喘。其中，21名受试者（25%）为吸烟者，60名（71.4%）为特应性患者。未发现eNO与每日哮喘症状评分、每日急救药物使用、β2受体激动剂后气道可逆百分比及HRQL之间存在相关性。
在一组与特应性和吸烟状况相关的异质性患者中，eNO测量在哮喘活动的临床评估中价值有限。
