Grotta J C
Department of Neurology, University of Texas Health Science Center Medical School, Houston 77030.
Clin Neuropharmacol. 1991 Oct;14(5):373-90. doi: 10.1097/00002826-199110000-00001.
Calcium antagonists may be useful for certain cerebrovascular conditions. In addition to producing a variable amount of cerebral vascular relaxation, high doses of some of these drugs may block calcium entry into neurons. Clinical trials in patients with vasospasm have clearly shown that calcium antagonists can improve outcome. Clinical trials in patients with acute stroke have been inconclusive, and have been flawed by delayed patient entry. Cardiovascular side effects may limit the safety and efficacy of calcium antagonists in acute stroke patients. Further investigation of early treatment with cerebroselective agents, possibly in conjunction with complementary therapies, is needed.
钙拮抗剂可能对某些脑血管疾病有用。除了产生不同程度的脑血管舒张作用外，其中一些药物的高剂量可能会阻止钙进入神经元。对血管痉挛患者的临床试验清楚地表明，钙拮抗剂可以改善预后。对急性中风患者的临床试验尚无定论，且因患者入组延迟而存在缺陷。心血管副作用可能会限制钙拮抗剂在急性中风患者中的安全性和有效性。需要进一步研究使用脑选择性药物进行早期治疗，可能与辅助治疗联合使用。
