Preś Krzysztof, Pośpiech Lucyna, Krecicki Tomasz, Nadolska Beata, Kubacka Marzena, Zatoński Tomasz, Jabłonka Agnieszka, Piechnik-Resler Dorota, Jankowska-Konsur Alina
Katedry i Kliniki Otolaryngologii, Akademii Medycznej we Wrocławiu.
Wiad Lek. 2006;59(11-12):797-800.
Malignant neoplasms of the nose and paranasal sinuses occur rarely but due to late diagnosis and poor treatment effects still remain a serious problem. The aim of the study was the analysis of all nose and paranasal sinus neoplasms treated at Lower Silesia in the years 1992-2001.
In the years 1992-2001 in Lower Silesia region there were 182 patients treated for malignant nose and paranasal sinus tumors. Males outnumbered females significantly with male : female ratio was 1.9:1. Principal management was combined therapy--surgery with radiotherapy in 84% of the cases. Radiotherapy alone was performed in 8.8% and chemotherapy as palliative treatment in 7.1%. Fifteen patients (8.2%) underwent radical neck dissection followed by radiotherapy.
The analysed group constituted 79.6% patients with epithelial tumors and 20.4% with nonepithelial tumors. Cases T3-T4 predominated in the material in amount of 77.9% (113). There were 15 T2 cases (10.4%) and none of T1. Most of the tumors (57%) arose from middle segment of ethmomaxillary sinuses. Upper segment tumors constituted 18.6% of cases and lower segment--10.4%. Enlarged lymph nodes were diagnosed in 8.2%. Survival rate analysis in patient treated in the years 1992-2001 revealed 37.9% (69) of 3-year survival and 30.2% (55) of 5-year survival.
Unsatisfactory results of treatment are an effect of a high advanced stage of the tumor while diagnosed. Its direct causes are: asymptomatic course of the disease, localization in complex anatomical structure, not enough experience among medical staff dealing with the disease very rarely.
鼻及鼻窦恶性肿瘤很少见，但由于诊断较晚且治疗效果不佳，仍然是一个严重的问题。本研究的目的是分析1992年至2001年在下西里西亚接受治疗的所有鼻及鼻窦肿瘤。
1992年至2001年在下西里西亚地区，有182例患者接受了鼻及鼻窦恶性肿瘤治疗。男性患者数量显著多于女性，男女比例为1.9:1。主要治疗方法是综合治疗——84%的病例采用手术加放疗。单独放疗的占8.8%，化疗作为姑息治疗的占7.1%。15例患者（8.2%）接受了根治性颈清扫术，随后进行放疗。
分析的病例组中，上皮性肿瘤患者占79.6%，非上皮性肿瘤患者占20.4%。材料中T3 - T4期病例占主导，数量为77.9%（113例）。有15例T2期病例（10.4%），无T1期病例。大多数肿瘤（57%）起源于筛上颌窦中段。上段肿瘤占病例的18.6%，下段肿瘤占10.4%。8.2%的患者诊断出淋巴结肿大。对1992年至2001年接受治疗患者的生存率分析显示，3年生存率为37.9%（69例），5年生存率为30.2%（55例）。
治疗结果不理想是肿瘤诊断时处于高度进展期的结果。其直接原因是：疾病无症状进程、位于复杂的解剖结构中、处理该疾病的医务人员经验不足且病例非常罕见。
