Chuapai Yaowaluk, Kiertiburanakul Sasisopin, Malathum Kumthorn, Sungkanuparph Somnuek
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand.
J Med Assoc Thai. 2007 Mar;90(3):452-8.
Lipodystrophy and dyslipidemia are increasing problems in HIV-infected patients receiving antiretroviral therapy (ART).
Determine the prevalence and predicting factors for lipodystrophy and dyslipidemia in these patients.
A cross-sectional study was performed on HIV-infected patients receiving ART in January 2006. Clinical assessment for lipodystrophy and blood tests for lipid profile were obtained.
There were 56 patients with a mean age of 42.3 years and 71.4% were male. Lipodystrophy was detected in 66.1%. Baseline characteristics between patients with and without lipodystrophy were similar except for age, history of receiving d4T and undetectable HIV-RNA (p < 0. 05). There was a high prevalence of dyslipidemia (53.6%). By logistic regression, undetectable HIV-RNA (odds ratio (OR) 6.4, p = 0.016) and receiving d4T (OR 7.4, p = 0.022) are predicting factors for lipodystrophy.
Lipodystrophy and dyslipidemia in HIV-infected Thai patients receiving ART are common. Clinical monitoring for these abnormalities during ART is highly recommended.
脂肪代谢障碍和血脂异常在接受抗逆转录病毒治疗（ART）的HIV感染患者中是日益严重的问题。
确定这些患者中脂肪代谢障碍和血脂异常的患病率及预测因素。
2006年1月对接受ART的HIV感染患者进行了一项横断面研究。获得了脂肪代谢障碍的临床评估和血脂水平的血液检测结果。
共有56例患者，平均年龄42.3岁，71.4%为男性。66.1%的患者检测出脂肪代谢障碍。除年龄、接受司他夫定（d4T）治疗史和无法检测到HIV-RNA外，有脂肪代谢障碍和无脂肪代谢障碍患者的基线特征相似（p<0.05）。血脂异常的患病率很高（53.6%）。通过逻辑回归分析，无法检测到HIV-RNA（比值比（OR）6.4，p = 0.016）和接受d4T治疗（OR 7.4，p = 0.022）是脂肪代谢障碍的预测因素。
接受ART的泰国HIV感染患者中脂肪代谢障碍和血脂异常很常见。强烈建议在ART期间对这些异常情况进行临床监测。
