Pelkonen Olavi
University of Oulu, Department of Pharmacology and Toxicology, Oulu, Finland.
Expert Opin Drug Metab Toxicol. 2007 Apr;3(2):147-8. doi: 10.1517/17425255.3.2.147.
In drug development, clinical trials are commonly carried out in either healthy volunteers or carefully selected patients. However, it has been recognised for a long time that both extremes of age, children and elderly, display a number of important metabolic and pharmacokinetic differences as compared with adults. This also has important consequences as to the toxic reactions and risk assessment of chemicals. What is known, what is not known and what should we do to improve the situation?
在药物研发过程中，临床试验通常在健康志愿者或精心挑选的患者中进行。然而，长期以来人们已经认识到，与成年人相比，儿童和老年人这两个极端年龄段在代谢和药代动力学方面存在一些重要差异。这对于化学品的毒性反应和风险评估也具有重要影响。目前已知哪些情况，未知哪些情况，我们应该采取什么措施来改善这种状况？
