Lee S-W, Kwon O-J, Park M-C, Oh H-B, Park Y-B, Lee S-K
Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Diseases, Brain Korea 21 Project for Medical Science, Graduate School of Yonsei University, College of Medicine, Seoul, Korea.
Clin Exp Rheumatol. 2007 Jan-Feb;25(1 Suppl 44):S18-22.
In this study, we investigated the HLA allele and haplotype frequencies, and the association of HLA alleles with serious complications and angiographic findings in Korean patients with Takayasu arteritis (TA) compared with healthy controls. Sixty-one patients (56 women, 5 men), diagnosed with TA between January 1995 and December 2005, were studied. Ninety-five healthy men and women were selected as controls. Clinical manifestations were assessed and angiographies were performed at the time of diagnosis in all TA patients. Genotypes of the HLA-A, -B and -DRB1 loci were determined using the polymerase chain reaction-sequencing-based typing (PCR-SBT) method. The mean age at the time of diagnosis of TA was 37.0+/-12.1 years. Compared with controls, the frequencies of A3001 (p=0.048), B5201 (p=0.025), and DRB11502 (p=0.046) alleles were significantly higher in TA patients, and the frequency of A2602 was significantly lower in TA patients when compared with controls (p=0.047). The haplotype containing A2402-B5201-DRB11502 was significantly increased in TA patients (chi2=5.45, p=0.01). Further, among the serious complication of TA, congestive heart failure (CHF) was found to be associated with B5201 (OR=5.94, p<0.05, 95% CI=1.04 33.85). These data suggest that A3001, B5201, and DRB11502 alleles might increase the susceptibility to TA, while A2602 might protect against TA. Further, our results reveal that the haplotype A2402-B5201-DRB11502 could be a risk factor for TA, and the allele B5201 is significantly associated with CHF.
在本研究中，我们调查了韩国高安动脉炎（TA）患者与健康对照相比的HLA等位基因和单倍型频率，以及HLA等位基因与严重并发症和血管造影结果之间的关联。研究对象为1995年1月至2005年12月期间诊断为TA的61例患者（56例女性，5例男性）。选取95例健康男性和女性作为对照。所有TA患者在诊断时评估临床表现并进行血管造影。使用基于聚合酶链反应测序的分型（PCR-SBT）方法确定HLA-A、-B和-DRB1位点的基因型。TA诊断时的平均年龄为37.0±12.1岁。与对照组相比，TA患者中A3001（p=0.048）、B5201（p=0.025）和DRB11502（p=0.046）等位基因的频率显著更高，而与对照组相比，TA患者中A2602的频率显著更低（p=0.047）。TA患者中含有A2402-B5201-DRB11502的单倍型显著增加（χ2=5.45，p=0.01）。此外，在TA的严重并发症中，发现充血性心力衰竭（CHF）与B5201相关（OR=5.94，p<0.05，95%CI=1.04 33.85）。这些数据表明，A3001、B5201和DRB11502等位基因可能增加TA易感性，而A2602可能对TA有保护作用。此外，我们的结果显示单倍型A2402-B开5201-DRB11502可能是TA的一个危险因素，且等位基因B5201与CHF显著相关。
