Zhang G, Hayden C M, Khoo S-K, Candelaria P, Laing I A, Turner S, Franklin P, Stick S, Landau L, Goldblatt J, Le Souëf P N
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia.
Eur Respir J. 2007 Jul;30(1):48-55. doi: 10.1183/09031936.00123206. Epub 2007 Apr 11.
The aim of the present study was to assess the effects of possible interactions between beta(2)-adrenoceptor gene polymorphisms and passive smoking on forced expiratory volume in one second (FEV(1)), forced vital capacity (FVC) and exhaled nitric oxide (eNO) in children aged 11 yrs. A cross-sectional analysis of the longitudinal cohort was conducted for associations between beta(2)-adrenoceptor gene polymorphisms and lung function and eNO with regard to passive smoking. Among children exposed to tobacco smoke, those with Arg16 (at least one Arg allele) exhibited lower adjusted mean FEV(1) (2.19 versus 2.38 L) and FVC (2.43 versus 2.64 L) than Gly16 homozygotes. Those with Gln27 (at least one Gln allele) also exhibited a lower adjusted mean FEV(1) relative to Glu27 homozygotes (2.24 versus 2.39 L). Among children with no exposure to smoking, those with Arg16 or Gln27 showed lower adjusted geometric mean eNO levels compared with Gly16 homozygotes (15.4 versus 30.9 ppb) and Glu27 homozygotes (18.0 versus 49.7 ppb). In conclusion, passive smoking had a significant effect on associations between beta(2)-adrenoceptor gene polymorphisms and asthma-related phenotypes, enhancing the relationship between Arg16 and lung function and removing the relationship between Arg16 or Gln27 and exhaled nitric oxide levels.
本研究的目的是评估β₂肾上腺素能受体基因多态性与被动吸烟之间可能的相互作用对11岁儿童一秒用力呼气容积（FEV₁）、用力肺活量（FVC）和呼出一氧化氮（eNO）的影响。针对β₂肾上腺素能受体基因多态性与肺功能及eNO之间关于被动吸烟的关联，对该纵向队列进行了横断面分析。在接触烟草烟雾的儿童中，携带Arg16（至少一个Arg等位基因）的儿童相较于Gly16纯合子，其调整后的平均FEV₁较低（2.19 L对2.38 L），FVC也较低（2.43 L对2.64 L）。携带Gln27（至少一个Gln等位基因）的儿童相较于Glu27纯合子，其调整后的平均FEV₁也较低（2.24 L对2.39 L）。在未接触吸烟的儿童中，携带Arg16或Gln27的儿童相较于Gly16纯合子（15.4 ppb对30.9 ppb）和Glu27纯合子（18.0 ppb对49.7 ppb），其调整后的几何平均eNO水平较低。总之，被动吸烟对β₂肾上腺素能受体基因多态性与哮喘相关表型之间的关联有显著影响，增强了Arg16与肺功能之间的关系，并消除了Arg16或Gln27与呼出一氧化氮水平之间的关系。
