Mahasin Z, Khan B
Departments of Surgery, and Biomedical Statistics and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ann Saudi Med. 1996 Sep;16(5):539-44. doi: 10.5144/0256-4947.1996.539.
From 1975 to 1985, 202 patients with hypopharyngeal cancer were seen at King Faisal Specialist Hospital and Research Centre (KFSH&RC). The endoscopic investigation showed that 28.3% of these patients had postcricoid carcinoma; 19.85% had pyriform fossa carcinoma and 52.9% had involvement of both sites. The pathological diagnosis of all cases was squamous cell carcinoma type. The majority of the patients (62.98%) had T4 lesions, which showed a late presentation to KFSH&RC. Information related to survival was available for a smaller number of patients due to many "lost-to-follow-up" cases. The overall median survival time was 8.5 months (1-110 months). The survival rate for each site was calculated, as well as the staging of the disease and treatment modality used. It appeared that pyriform fossa (median 21 months) had the best survival rate. In addition, the earlier the lesion was detected and the more aggressive the treatment applied, the better the survival rate. Fifty percent of the patients receiving radiation therapy and surgery had a five-year survival rate. Factors other than smoking and/or drinking should be looked for in our community as predisposing to this disease in our population.
1975年至1985年期间，费萨尔国王专科医院及研究中心（KFSH&RC）共收治了202例下咽癌患者。内镜检查显示，这些患者中28.3%患有环状软骨后癌；19.85%患有梨状窝癌，52.9%两个部位均受累。所有病例的病理诊断均为鳞状细胞癌类型。大多数患者（62.98%）患有T4期病变，这表明他们在KFSH&RC就诊时已处于疾病晚期。由于许多患者“失访”，仅有少数患者的生存信息可供使用。总体中位生存时间为8.5个月（1至110个月）。计算了每个部位的生存率、疾病分期以及所采用的治疗方式。结果显示，梨状窝（中位生存时间21个月）的生存率最高。此外，病变发现得越早，治疗越积极，生存率就越高。接受放疗和手术的患者中有50%的人有五年生存率。在我们的社区中，除了吸烟和/或饮酒之外，还应寻找其他导致我们人群易患此病的因素。
