[HIV-1感染患者长期不进展者与典型进展者之间CD4+T淋巴细胞活化的差异]
[Difference in the CD4+T lymphocytes activation between long term non-progressors and typical progressors of HIV-1 infected patients].
作者信息
Jiao Yan-mei, Fu Jun-liang, Zhang Zheng, Zhang Hui, Jin Lei, Zhou Chun-bao, Fu Bao-yun, Wang Fu-sheng, Wu Hao
机构信息
Beijing You-an Hospital Affiliated to Capital University of Medical Sciences, Beijing 100054, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Mar;21(1):11-3.
OBJECTIVE
To investigate the difference in the CD4+T lymphocytes activation between long term non progressors (LTNP) and typical progressors (TP) of HIV-1 infected patients.
METHODS
Twenty-four HIV-1 infected patients and 15 heathy control adults were tested and flow cytometry was used to detect the activation marker CD38 and CD4 count in blood samples taken from the patients and control. bDNA method was used to test the virus load in the plasma of patients.
RESULTS
The activation of CD4+T cells was positively correlated with virus load and negatively correlated with CD4 counts. Compared with normal controls, the activation of CD4+T cells was obviously increased in TP patients but not obviously changed in LTNP patients.
CONCLUSION
Compared with healthy controls, the activation of CD4+T cells in LTNP did not obviously increase. This maybe partially accounts for LTNP patients keeping a good state for a long time.
目的
探讨人类免疫缺陷病毒1型（HIV-1）感染患者中长期无进展者（LTNP）与典型进展者（TP）之间CD4+T淋巴细胞活化的差异。
方法
对24例HIV-1感染患者和15名健康对照成年人进行检测，采用流式细胞术检测患者和对照者血样中的活化标志物CD38及CD4计数。采用分支DNA法检测患者血浆中的病毒载量。
结果
CD4+T细胞活化与病毒载量呈正相关，与CD4计数呈负相关。与正常对照相比，TP患者CD4+T细胞活化明显增加，而LTNP患者无明显变化。
结论
与健康对照相比，LTNP患者CD4+T细胞活化未明显增加。这可能部分解释了LTNP患者长期保持良好状态的原因。
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