[使用5-氨基酮戊酸光动力疗法治疗单纯疱疹病毒感染的实验研究]
[Experimental studies on treatment of HSV infections with photodynamic therapy using 5-aminolevulinic acid].
作者信息
Tao Ji-ning, Duan Shu-min, Li Jun
机构信息
Shanghai Fudan-Zhangjiang Bio-pharmaceutical Co., Ltd, Shanghai 201203, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Mar;21(1):79-82.
OBJECTIVE
To investigate in vitro and in vivo anti-human herpes simplex virus effects of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA).
METHODS
Guinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT.
RESULTS
The in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related.
CONCLUSION
ALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections.
目的
研究使用5-氨基酮戊酸（ALA）的光动力疗法（PDT）在体外和体内对人单纯疱疹病毒的作用。
方法
应用豚鼠皮肤疱疹病毒感染模型，并将感染单纯疱疹病毒I型（HSV-I）和II型（HSV-II）的非洲绿猴肾细胞（Vero细胞）作为实验系统，观察ALA-PDT的抗疱疹作用。
结果
体外实验表明，ALA-PDT对HSV-I和HSV-II具有抗疱疹作用，其效果与阿昔洛韦相似。动物实验结果表明，ALA-PDT对豚鼠皮肤疱疹病毒感染模型具有显著治疗作用，且该作用与剂量相关。
结论
ALA-PDT可有效治疗HSV感染，这可能为病毒感染的治疗提供一种新方法。
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