Levitas E, Lunenfeld E, Weisz N, Friger M, Potashnik G
Fertility and IVF Unit, Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Andrologia. 2007 Apr;39(2):45-50. doi: 10.1111/j.1439-0272.2007.00761.x.
This study evaluates retrospectively the relationship between age and semen parameters among men with normal sperm concentration. It was based on computerized data and performed in an Academic Fertility and IVF Unit. Six thousand and twenty-two semen samples with sperm concentrations of >or=20 x 10(6) ml(-1) were examined according to WHO criteria and analysed in relation to patients' age. For each age group, mean values +/- SD of semen volume, sperm concentration, percentage of motile spermatozoa, normal morphology, acrosome index, total sperm count/ejaculate, total motile sperm count/ejaculate and sexual abstinence duration were examined. A peak semen volume of 3.51 +/- 1.76 ml(-1) was observed at age >or=30 to <35 years and a lowest volume of 2.21 +/- 1.23 ml(-1) was observed at age >or=55 years (P<0.05). Sperm motility was found to be inversely related to age with peak motility of 44.39 +/- 20.69% at age <25 years and lowest motility of 24.76 +/- 18.27% at age >or=55 years (P<0.05). A reduction of 54% was observed for total motile sperm, between values of 103.34 +/- 107 x 10(6) at age >or=30 to <35 years and 46.68 +/- 53.73 x 10(6) (P<0.05) at age >55 years. A statistically significant and inverse relationship was observed between semen volume, sperm quality and patient age, in spite of prolonged sexual abstinence duration. Top sperm parameters were observed at age >or=30 to <35 years, while the most significant reduction in sperm parameters occurred after the age of 55 years.
本研究回顾性评估了精子浓度正常的男性年龄与精液参数之间的关系。该研究基于计算机化数据，在一家学术性生育与试管婴儿中心进行。根据世界卫生组织标准，对6022份精子浓度≥20×10⁶/ml⁻¹的精液样本进行了检查，并分析了其与患者年龄的关系。对每个年龄组的精液体积、精子浓度、活动精子百分比、正常形态、顶体指数、每次射精的总精子数、活动精子总数以及禁欲时间的平均值±标准差进行了检测。精液体积在年龄≥30至<35岁时出现峰值，为3.51±1.76ml⁻¹，在年龄≥55岁时出现最低值，为2.21±1.23ml⁻¹（P<0.05）。发现精子活力与年龄呈负相关，在年龄<25岁时活力峰值为44.39±20.69%，在年龄≥55岁时活力最低，为24.76±18.27%（P<0.05）。活动精子总数在年龄≥30至<35岁时为103.34±107×10⁶，在年龄>55岁时为46.68±53.73×10⁶，减少了54%（P<0.05）。尽管禁欲时间延长，但仍观察到精液体积、精子质量与患者年龄之间存在统计学上显著的负相关关系。在年龄≥30至<35岁时观察到最佳精子参数，而精子参数在55岁以后出现最显著下降。
