Feki N Chakroun, Abid N, Rebai A, Sellami A, Ayed B Ben, Guermazi M, Bahloul A, Rebai T, Ammar L Keskes
Laboratory of Histology & Embryology, Medical School of Sfax, Sfax, Tunisia.
J Androl. 2009 Sep-Oct;30(5):541-7. doi: 10.2164/jandrol.108.005959. Epub 2009 Feb 5.
Concerns about the worldwide decline in semen quality over the past 50 years are increasing. Western countries have shown a decline in semen quality. However, in non-Western countries studies are sparse. We investigated trends in semen parameters between 1996 and 2007 in the Sfax area of southern Tunisia in a sample of 2940 men in infertile relationships. Age at semen collection, duration of sexual abstinence, volume of seminal fluid, the sperm count, percentages of motile and morphologically normal spermatozoa, and semen leukocyte concentration were determined. Linear regression was used to examine trends over time in sperm count, sperm motility, normal morphology, and semen leukocyte concentration. Mean age and semen volume did not change between 1996 and 2007. Data adjusted for age and abstinence showed a decreasing trend in sperm count and percentage of normal morphology over the last 12 years (R(2) = 0.71, P = .0004, and R(2) = 0.87, P < .0001, respectively). There was no significant change in sperm motility. However, semen leukocyte concentration increased significantly over time (R(2) = 0.38, P = .03). These results coincide with the high prevalence of genital infectious diseases in the Sfax area, suggesting that infection may be a potential contributing factor in semen quality decline.
过去50年来，全球精液质量下降的问题日益受到关注。西方国家已出现精液质量下降的情况。然而，在非西方国家，相关研究较少。我们对突尼斯南部斯法克斯地区2940名不育男性进行了调查，研究1996年至2007年期间精液参数的变化趋势。测定了精液采集时的年龄、禁欲时间、精液量、精子数量、活动精子百分比、形态正常精子百分比以及精液白细胞浓度。采用线性回归分析精子数量、精子活力、正常形态精子百分比和精液白细胞浓度随时间的变化趋势。1996年至2007年期间，平均年龄和精液量未发生变化。经年龄和禁欲时间校正后的数据显示，在过去12年中，精子数量和正常形态精子百分比呈下降趋势（R²分别为0.71，P = 0.0004和R²为0.87，P < 0.0001）。精子活力无显著变化。然而，精液白细胞浓度随时间显著增加（R² = 0.38，P = 0.03）。这些结果与斯法克斯地区生殖器感染疾病的高患病率相符，表明感染可能是精液质量下降的一个潜在因素。
