Singh Pritpal, Taylor Simon F, Murali Rajmohan, Gomes Lavier J, Kanthan Gowri L, Maloof Anthony J
Department of Ophthalmology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Affiliated Teaching Hospital with the University of Sydney, Sydney, New South Wales, Australia.
Clin Exp Ophthalmol. 2007 Apr;35(3):275-80. doi: 10.1111/j.1442-9071.2007.01458.x.
Disseminated mucormycosis, with pulmonary and cerebral angioinvasive disease, developed in a 65-year-old woman with rheumatoid arthritis being treated with combination immunosuppression including adalimumab. Clinical presentation included progressive orbital ischaemia. To the best of the authors' knowledge, this is the first reported case of disseminated mucormycosis in a patient treated with a tumour necrosis factor inhibitor. Important pathophysiological factors are considered.
一名65岁患类风湿关节炎的女性在接受包括阿达木单抗在内的联合免疫抑制治疗时，发生了播散性毛霉病，并伴有肺部和脑部血管侵袭性疾病。临床表现包括进行性眼眶缺血。据作者所知，这是首例接受肿瘤坏死因子抑制剂治疗的患者发生播散性毛霉病的报告病例。文中考虑了重要的病理生理因素。
