Reschini E, Catania A
Department of Nuclear Medicine, Ospedale Maggiore di Milano, Italy.
Eur J Nucl Med. 1991;18(10):817-23. doi: 10.1007/BF00175061.
Adrenocortical scintigraphy with iodine 131-19-iodocholesterol or selenium 75-6-selenomethylcholesterol was performed in 94 patients with proven or suspected adrenal disease. According to the final diagnosis, 36 patients suffered from primary aldosteronism, 33 from Cushing's syndrome, 8 from low renin hypertension, 6 from nonfunctioning adrenal tumour, 4 from simple obesity, 3 from adrenal metastases, 1 from congenital adrenal hyperplasia, 1 from virilizing adrenal adenoma, 1 from extraadrenal phaeochromocytoma, 1 from ganglioneuroma. Surgical confirmation of the diagnosis was obtained in most cases. With a few exceptions, the scintigraphy results were consistent with the final diagnosis. The two tracers were equally effective adrenal scanning agents. Tracer concentration was measured in a number of surgical specimens, mostly from patients given selenocholesterol. This measurement in surgical samples has not been reported in previous studies with this agent. The results provided a direct validation of uptake measurements in vivo. The data, collected over a 17-year period, demonstrate that despite the advent of new imaging techniques, adrenal scintigraphy that gives both functional and morphologic information still has an important role in the diagnosis of adrenal disease.
对94例已证实或疑似肾上腺疾病的患者进行了用碘131-19-碘胆固醇或硒75-6-硒甲基胆固醇的肾上腺皮质闪烁显像。根据最终诊断，36例患有原发性醛固酮增多症，33例患有库欣综合征，8例患有低肾素性高血压，6例患有无功能肾上腺肿瘤，4例患有单纯性肥胖，3例患有肾上腺转移瘤，1例患有先天性肾上腺增生，1例患有男性化肾上腺腺瘤，1例患有肾上腺外嗜铬细胞瘤，1例患有神经节瘤。大多数病例通过手术证实了诊断。除少数例外，闪烁显像结果与最终诊断一致。这两种示踪剂是同样有效的肾上腺扫描剂。在一些手术标本中测量了示踪剂浓度，大多数标本来自给予硒胆固醇的患者。此前使用该试剂的研究中尚未报道过在手术样本中的这种测量。结果为体内摄取测量提供了直接验证。在17年期间收集的数据表明，尽管出现了新的成像技术，但能提供功能和形态学信息的肾上腺闪烁显像在肾上腺疾病的诊断中仍具有重要作用。
