缺乏1-磷酸半乳糖尿苷转移酶的小鼠中尿苷二磷酸半乳糖焦磷酸化酶功能的证据。
Evidence for function of UDP galactose pyrophosphorylase in mice with absent galactose-1-phosphate uridyltransferase.
作者信息
Wehrli Suzanne, Reynolds Robert, Segal Stanton
机构信息
NMR Core Facility, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
出版信息
Mol Genet Metab. 2007 Jun;91(2):191-4. doi: 10.1016/j.ymgme.2007.02.013. Epub 2007 Apr 11.
Mice with deletion of the galactose-1-phosphate uridyltransferase (GALT) gene were examined for their ability to form (13)C labeled hepatic UDP glucose from administered 1-(13)C galactose. NMR analysis of urinary acetaminophen glucuronide, which is derived from hepatic UDP glucose showed (13)C enrichment after concomitant administration of (13)C galactose and acetaminophen. The finding is consistent with the function of UDP galactose pyrophosphorylase as an alternate pathway of galactose metabolism.
对缺乏1-磷酸半乳糖尿苷酰转移酶（GALT）基因的小鼠进行了检测，以研究其利用给予的1-（13）C半乳糖生成（13）C标记的肝UDP葡萄糖的能力。尿中对乙酰氨基酚葡萄糖醛酸苷源自肝UDP葡萄糖，对其进行核磁共振分析显示，在同时给予（13）C半乳糖和对乙酰氨基酚后，其出现了（13）C富集。这一发现与UDP半乳糖焦磷酸化酶作为半乳糖代谢的替代途径的功能是一致的。
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