Keir Mary E, Francisco Loise M, Sharpe Arlene H
Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Curr Opin Immunol. 2007 Jun;19(3):309-14. doi: 10.1016/j.coi.2007.04.012. Epub 2007 Apr 12.
The past year has seen significant advances in our understanding of the critical roles of negative immunoregulatory signals delivered by the programmed death 1 (PD-1)-PD-1 ligand (PD-L) pathway in regulating T-cell activation and tolerance. Emerging evidence indicates that PD-Ls play an essential role on dendritic cells (DCs), both directly during DC-T cell interactions and indirectly through signaling into the DC. Recent studies point to a novel role for PD-L1 in maintaining tissue tolerance. Finally, PD-1 has recently been shown to be highly expressed on exhausted T cells during chronic viral infection, and blockade of PD-1 or PD-L1 can revive exhausted T cells, enabling them to proliferate and produce effector cytokines.
过去一年，我们对程序性死亡1（PD-1）-PD-1配体（PD-L）通路传递的负性免疫调节信号在调节T细胞活化和耐受中的关键作用有了重大进展。新出现的证据表明，PD-L在树突状细胞（DC）上起着至关重要的作用，无论是在DC与T细胞相互作用期间直接发挥作用，还是通过向DC发出信号间接发挥作用。最近的研究指出PD-L1在维持组织耐受方面有新作用。最后，最近研究表明，在慢性病毒感染期间，耗竭的T细胞上PD-1高度表达，阻断PD-1或PD-L1可使耗竭的T细胞恢复活力，使其能够增殖并产生效应细胞因子。
