Bezemer Irene D, Rosendaal Frits R
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Semin Hematol. 2007 Apr;44(2):85-92. doi: 10.1053/j.seminhematol.2007.01.007.
Various pathways lead to the development of venous thrombosis. Risk factors are common and can be genetic or acquired. Since the identification of factor V Leiden and prothrombin 20210 G-->A, the field of genetic epidemiology has developed rapidly and many new genetic variants have been described in the past decade. However, the association with venous thrombosis is often unclear and conflicting results have been reported in various studies. The aim of this review is to describe these candidate predictors of venous thrombosis and to put these in perspective.
多种途径可导致静脉血栓形成。危险因素很常见，可分为遗传性或后天性。自从发现因子V莱顿突变和凝血酶原20210 G→A突变以来，遗传流行病学领域发展迅速，在过去十年中描述了许多新的基因变异。然而，与静脉血栓形成的关联往往不明确，各项研究报告的结果相互矛盾。本综述的目的是描述这些静脉血栓形成的候选预测因素，并对其进行综合考量。
